Tailoring the Treatment of Early-stage HER2-positive Breast Cancer: One Size Does Not Fit All

نویسندگان

چکیده

Human epidermal growth factor receptor-2 (HER2)-positive breast cancer accounts for 15% of all cancers and this subtype was historically associated with poor outcomes. The development HER2-directed therapies has dramatically improved outcomes patients early advanced HER2+ disease. Trastuzumab is a HER2-targeted monoclonal antibody first approved the treatment in late 1990s. Since then, it been shown to improve long-term early-stage disease, particularly when given combination chemotherapy (neo)adjuvant setting. Pertuzumab another that targets different domain HER2 receptor from trastuzumab prevents HER2–HER3 dimerization. addition pertuzumab disease; drug also studied setting proved lymph node involvement. Neratinib emtansine adjuvant have selected high-risk patients. As more effective options developed cancer, we progressively moved one-size-fits-all approach towards tailored paradigm. In narrative review, summarize diagnosis prognosis as well current approaches.

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ژورنال

عنوان ژورنال: Touch reviews in oncology & haematology

سال: 2023

ISSN: ['2752-5481']

DOI: https://doi.org/10.17925/ohr.2023.19.1.11